| 초록 |
Gelatin, a natural macromolecule, is widely used in biomedical and biotechnological applications and is a good candidate for preparation of microspheres and microcapsules for the purpose of controlled release applications of drugs. Gelatin Microspheres(GMs), one of the applications as biomaterials, are being used for drug delivery system, embolic, and injectable filler. The aim of this study was to investigate the influence of stability as the various storage condition on GMs chemico-physical characteristics. In this study, GMs were prepared by free fall microdroplets technique(FFMt) and were investigated using analytical methods, such as pH, viscosity, SEM, and XPS. The changing value of GMs from external condition was measured at different gelatin concentrations (1%, 2%, 3% w/v) and temperatures during a particular period of time. Also, characteristics of GMs structure including size, appearance, and uniformity of particles and elemental composition was investigated. |
