| 초록 |
This work aims at studying the effect of the modified composite films on the cell strategies and surface properties. The excellent biodegradable synthetic materials with various ratios of chitosan, gelatin and calcium phosphate were prepared, using a solvent casting method from a blend of chitosan, gelatin and calcium phosphate. The model films casted from the initial components were also studied. Contact angle measured after coating calcium phosphate on chitosan/gelatin film decreased indicating that the wettability of the film was increased. In addition, fibroblast (NIH3T3) attachment and growth on the films were significantly enhanced on the composite films. Modification of chitosan, gelatin and calcium phosphate films resulted in a substantial increase in fibroblast viability. The results show that new synthesized biodegradable materials possessed good flexibility for cellular attachment, spreading, and proliferation, which may promise broad prospects in biomedicals fields such as promote wound healing and antibacterial activity. |
