| 초록 |
Nanoparticles such as PEGylated liposomes, dendrimers, carbon nanotubes, and antimicrobial peptides have biomedical applications such as antitumor therapeutics and drug delivery. These applications require the understanding on the interaction of those with cell membranes, thus interactions of PEGylated nanoparticles, biopolymers, and membranes have been studied using all-atom and coarse-grained molecular dynamics simulations. The following topics will be presented: (1) conformation and hydrodynamics of PEG; (2) self-assembly and phase behavior of PEGylated liposomes, bicelles, and micelles; (3) lipid bilayer curvature and pore formation induced by differently sized, shaped, charged, and concentrated PEGylated peptides and nanoparticles; (4) adsorption of plasma proteins onto PEGylated lipid bilayers: the effect of PEG size and grafting density. This work aids in the rational design of nanoparticle size, shape, and surface properties for nanomedicine applications. |
