| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
신진과학자포럼(추계) |
| 제목 |
Assessing the effect of surface chemistry on cellular uptake, trafficking, and degradation |
| 초록 |
Nanoparticles have been attracting tremendous attention for drug delivery and bioimaging up to date. However, it remains questions how to optimally synthesize and chemically modify nanomaterials for in vivo applications. Here, we investigate the role of surface chemistry in mediating serum protein adsorption to the nanoparticles and their cellular uptake. To suppress protein adsorption or nonspecific bindings, researchers often functionalize the nanoparticle surface with the antifouling polyethylene glycol (PEG). The relative density of the serum proteins depends on the nanoparticle size and the PEG grafting density, and variations in serum protein adsorption is further correlated with the uptake mechanism and efficiency of nanoparticle. The study provides controllable manner of nanoparticle uptake by changing nanoparticle size and surface chemistry, and ultimately establishes principles for the rational design of clinically useful nanoparticle for translational uses of nanomedicine. |
| 저자 |
주진명 |
| 소속 |
울산과학기술원 |
| 키워드 |
nanoparticle; nano-bio; drug delivery system; bioimaging
|
| E-Mail |
|
