| 초록 |
In recent decades, cancer treatments using nanomedicine have come into attention due to their benefits of preferential accumulation in tumor tissues through the enhanced permeation and retention (EPR) effect. Compared to superior efficacy in preclinical studies, however, the EPR effect has been shown as insufficient to deliver therapeutic agents in the tumor tissue in clinical trials. In this reason, we prepared the block copolymer which can generate nitric oxide (NO) in tumor tissues and dilate the adjacent blood vessels. The amphiphilic nature of copolymers allows self-assembly under the aqueous. When the NO-generating nanoparticles were administered systemically, vascular permeability, blood flow, and drug accumulation in tumor tissues increased compared to control groups. The in vivo results suggested that our nanoparticles might be the potent drug carrier to induce tumor-specific NO-mediated vasodilation and the improved EPR effect |
