| 초록 |
Tannic acid (TA) not only has anti-cancer properties but also prevents sticking of drug carriers (or peptides) to the glycocalyx layer of vascular endothelial cells, thus enabling drug delivery with high targeting efficiency. In this study, we propose a nanovesicles system of which lipid bilayer was decorated with TA for enhanced cancer cell therapy. For this, we fabricated TANNylated nanovesicles by employing thiol-maleimide reaction between TA deriatives and lipid molecules. To evaluate their cancer cell targeting treatment efficacy, the degree of apoptosis was characterized via fluorescence-activated cell sorting analysis. Finally, we showed that our TANNylated nanovesicles have potential for high-efficiency cancer cell apoptosis induction, thus promising practical applicability for targeted cancer cell therapy. |
