| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
나노 |
| 제목 |
Conducting Polymer Nanotube Based in-vitro Dopamine Aptasensor |
| 초록 |
In this study, ultrasensitive and precise detection of a representative brain hormone, dopamine was pursued and demonstrated using functional conducting polymer nanotubes modified with aptamer. The produced aptasensor was composed of a micropatterned gold electrode, carboxylated polypyrrole nanotubes, and specific aptamer molecules. The sensor was constructed by sequential deposition of the PPy-COOH nanotubes and aptamer molecules on the electrode. The sensitivity and selectivity of this sensor were monitored using field effect transistor type measurements. In addition, real dopamine released from PC12 and SH-SY5Y cells induced by high concentration potassium ion (K+) stimulus were also analyzed and compared with the data obtained from the sensitivity (1 nM) and selectivity tests. This article can provide the feasibility for practical use of simple and efficient field effect transistor type aptasensor. |
| 저자 |
이지연1, 서성은1, 구교은1, 권오석1, 배준원2
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| 소속 |
1한국생명공학(연), 2동덕여자대 |
| 키워드 |
Aptasensor; Dopamine; Conducting Polymer; Polypyrrole; Nanotubes
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| E-Mail |
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