| 학회 | 한국공업화학회 |
| 학술대회 | 2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 | 19권 2호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | PCL microsphere-based scaffolds which contain alendronate for bone disease treatment |
| 초록 | As the elderly population is rapidly growing, bone diseases such as osteoporosis are continuously increasing. Hence, biomaterials for the restoration of damaged tissues are urgently demanded. In this study, we investigated Poly(ε-caprolactone) (PCL) scaffold as drug delivery carrier for the bone disease treatment. The scaffold was prepared using PCL microspheres which contain alendronate. The physicochemical property and biological function of the scaffold were analyzed. Cytotoxicity of the scaffold was examined using cell proliferation and differentiation. Our result demonstrated that the drug incorporation is strongly promoted osteoblast responses, including proliferation and differentiation. Our drug-carrying scaffold can be a potential candidate for the repair of bone damage. This research was supported by the Ministry of Trade, Industry and Energy(MOTIE), KOREA, through the Education Program for Creative and Industrial Convergence. (Grant Number N0000717) |
| 저자 | Le Thi Kim Tram, 이수희, 김주승, 임진익, 이우걸, 정은진 |
| 소속 | 단국대 |
| 키워드 | PCL scaffolds; microspheres; alendronate; cytotoxicity |
