| 초록 |
Various pollutants in the atmosphere can cause damage to living organisms, nature, and also humans. The toxicity of air pollution has been of interest due to the increasing concerns about healthcare. Extremely small sized particulate matter (PM) in the atmosphere penetrates blood vessel through the alveoli and cause developmental disability of fetus. Induced pluripotent stem cells (iPSCs) can be differentiated to various cell types and are promising cell source for regenerative medicine. In this study, we analyzed the effect of PM on iPSCs to examine the impact of PM on fetus indirectly. PM consists of various materials such as organic compounds, carbon blacks and hydrocarbons. Dimensional effect of carbon materials could be analyzed by using 2D graphene oxide (GO). GO sheets were categorized depending on their lateral sheets size. Surface morphologies, cellular uptake, surface adhesion and differentiation behavior of iPSCs co-cultured with categorized GO sheets were analyzed. |
