| 초록 |
The amphiphilic dipeptides bearing pyrene and phenylboronic acid was demonstrated as a unique example of a ratiometric or turn-on sensing system for sugars in aqueous solutions. We reported a novel ratiometric sensing system based on amphiphilic peptide probes bearing monoboronic acid for the improved glucose selectivity in aqueous buffered solution. Interestingly, the amphiphilic peptide sensor bearing monoborinic acid aggregated in the presence of Glu, resulting in the sensitive and selective ratiometric response to Glu over the other sugars such as Fru, Man, and Gal in aqueous solution at physiological pH. The amphiphilic peptide sensor sensitively detected 10~1000 uM concentration of Glu in artificial urine by ratiometric response. We further demonstarated a phenylboronic acid moiety of the peptide probes acts as a carbohydrate receptor as well as a fluorescence quencher for the pyrene.
|
