| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 봄 (04/20 ~ 04/21, 대구 인터불고 호텔) |
| 권호 |
12권 1호, p.7 |
| 발표분야 |
고분자 |
| 제목 |
Novel pH-sensitive polyaspartamide nano-aggregates grafted with 1-(3-aminopropyl)imidazole for intracellular drug delivery application |
| 초록 |
Novel pH-sensitive and biodegradable polyaspartamide derivatives were developed by simple grafting of 1-(3-aminopyl)imidazole and/or O-(2-aminoethyl)-O’-methylpolyethylene glycol 5000 on PSI. The prepared polymers showed sharp pH-dependent phase transition around pH 7 by the protonation or unprotonation of the imidazole rings and had high buffering capacity between pH 5 and 7. For the MPEG/imdazole-g-polyaspartamides with the degree of substitution of 1-(3-aminopropyl)imidazole over 82%, the self aggregates associated with the hydrophobic interaction of the unprotonated imidazole groups were observed above pH 7, and their mean size was over 200 nm, while the aggregates of polymers were dissociated below pH 7 by protonation of imidazole groups. The pH-sensitive polyasparamide derivatives are worth basic candidates for the intracellular drug delivery carriers triggered by small pH changes. |
| 저자 |
서광원, 김덕준
|
| 소속 |
성균관대 |
| 키워드 |
pH-sensitive polymers; drug delivery systems; graft copolymers
|
| E-Mail |
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| 원문파일 |
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