| 초록 |
Herein, we have developed a customizable fibrous site-specific drug-delivery platform functionalized with multiple stimuli-responsive polypyrrole (PPy) for the combination treatment via photothermal ablation and chemotherapy. Primarily, the drug-loaded polymeric electrospun mat was fabricated, followed by functionalization with stimuli-responsive materials. The final products exhibited excellent photostability and heating property in response to near-infrared (NIR) exposure. PPy-coated mats exhibited enhanced drug release in a pH 5.5 environment compared to pH 7.4. The release was further accelerated in response to NIR under both conditions; however, the superior release was observed at pH 5.5 compared to pH 7.4, indicating a dual stimuli-responsive drug-delivery platform. PPy-coated drug-loaded mats presented significantly enhanced in vitro and in vivo anticancer efficacy under NIR irradiation compared to mats not exposed to NIR or non-functionalized mats. |
