| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Self-Assembled Nano/Micro-Particles Based on Thermosensitive Human Tropoelastin as Vehicles for Protein Delivery |
| 초록 |
The structural protein elastin is one of the main components of the extracellular matrix, which provides structural integrity to the tissues and organs of the body. Not only elastin but also its precursor material, tropoelastin, have inspired for many years because of its ability to self-assemble under physiological conditions. We describe here the fabrication of insulin-loaded nano/micro-particles using tropoelastin derived from human adipose tissue. Human tropoelastin can be self-assembled into spherical nano/micro-particles of various sizes at body temperature and the nano/micro-particles with multicore structure exhibited a high protein loading efficiency. The self-assembled tropoelastin nano/micro-particles are able to encapsulate significant amounts of insulin by simple mixing at low temperature in water and heating up to body temperature. These thermoresponsive tropoelastin nano/micro-particles have great potential as a smart protein/drug delivery system. |
| 저자 |
정연제, 우창희, 이경수, 최지숙, 조용우
|
| 소속 |
한양대 |
| 키워드 |
Human tropoelastin; Thermoresponsive; Self-assembly; Nano/Micro particle; Protein delivery
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| E-Mail |
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