| 초록 |
Nitric oxide (NO) is a physiological molecule that plays a key role in our body. In respect of inflammation, NO is known to be related with RA, a chronic autoimmune disease that involves the joints. In our group, we already reported NO-responsive macro-sized hydrogel by synthesizing NO-cleavable crosslinker. Herein, we further investigate NO-responsive nanogel. The abnormal macrophage in the RA lesion secretes much higher concentration of NO compared with normal one. Thus, we designed NO-responsive nanogel that removes NO in abnormal joint. We represented the formation of the nanogel using acrylamide and NO-cleavable linker and confirmed high NO capturing efficiency of NO-responsive nanogel. We also showed the therapeutic effect of the nanogel in suppression of the onset of arthritis in each paw of mice was more effective than dexamethasone, a commercial anti-rheumatoid arthritis drug. Therefore, our findings may suggest a potential biomedical application for clinical translation. |
