| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Remission of rheumatoid arthritis using methotrexate loaded dextran sulfate nanoparticle: A theranostic approach. |
| 초록 |
Rheumatoid arthritis (RA) is an autoimmune disease cause’s dysregulated inflammation in the joints. Up to 1% of population affected by RA in industrialized countries. Although the exact cause of RA is unknown, the articular inflammation is majorly contributed by activated macrophages. Therefore targeting activated macrophages has been considered as a promising strategy for RA treatment. We prepared methotrexate (MTX) loaded dextran sulfate nanoparticles (DSNPs) for targeted delivery of MTX to inflamed joints in RA. The physicochemical characterization of DSNPs was investigated using various instruments. The DSNPs effectively accumulated in inflamed joints after systemic administration into mice, implying their high targetability to RA tissues. As well as the MTX-loaded DSNPs showed significantly improved therapeutic efficacy against mice with collagen-induced arthritis (CIA). Overall, the DSNPs have a prominent potential as a therapeutic agent for RA imaging and therapy. |
| 저자 |
Wilbin Xavier1, 허로운2, 유동길2, 박재형2
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| 소속 |
1SungKyunKwan Univ., 2Sungkyunkwan Univ. |
| 키워드 |
Rheumatoid arthritis; theranostic nanoparticle; dextran sulfate
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| E-Mail |
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