| 초록 |
Silicon nanoparticles (Si NPs) has developed for application in medicine because of their biocompatibility, biodegradability, drug loading and imaging agents. Herein, we report a solution synthesis of Si NPs as hyperpolarized magnetic resonance imaging. The Si NPs was synthesized by the reduction of silicon tetrachloride using organic reductants at low temperature. This nanoparticles size was controlled by investigation ratio of silicon precursor to reductant, temperature. The chloride-terminated Si NPs was converted to silanization-terminated through methoxy-capped. The morphology, structure and physical properties of Si NPs were confirmed by transmission electron microscopy (TEM), X-ray diffraction (XRD), infrared spectroscopy (IR spectroscopy) and dynamic light scattering (DLS). This research recommends that controlling the size of silicon nanoparticles via colloidal synthesis as the contrast agents for hyperpolarized 29Si magnetic resonance imaging. |
