| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.339 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Galactosylated Poly(4-vinyl imidazole) as Hepatocyte-Targeting Gene Carrier |
| 초록 | The use of non-viral gene carrier such as cationic polymers or cationic lipids may overcome the current problems associated with viral gene carrier in safety, immunogenicity and mutagenesis. In this study, poly(4-vinylimidazole) (P4V) of which the side chain is similar to that of natural amino acid, histidine, was used as a gene carrier and conjugated to lactobionic acid bearing galactose group for liver specificity. The Gal-P4V/DNA complex was confirmed using agarose gel electrophoresis. The sizes and zeta potential of the complex were measured by light scattering. The cytotoxicity of Gal-P4V was evaluated. The Gal-P4V/DNA complex was transfected into HepG2 cells having asialoglycoprotein receptors (ASGR), indication of specific interaction of ASGR on HepG2 cells and galactose ligands on Gal-P4V. |
| 저자 | 국승은;박인규;T. Akaike;조종수 |
| 소속 | 서울대 농생명공학부;서울대 농생명공학부;Tokyo Institute of Technology |
| 키워드 | poly(4-vinylimidazole); hepatocyte-targeting; gene carrier |
