| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Bio-inspired Surface Imobilization of Hyaluronic Acid on Monodisperse Magnetic Nano-crystals for Targeted Cancer Imaging |
| 초록 |
We report a simple and biologically compatible reaction of homogeneous and stable immobiliza-tion of hyaluronic acid (HA) on mono-disperse magnetite nanocrystal surface using dopamine as an anchor (HA-MNC). To accomplish surface-specific reaction, we adopted temporary surface charge on magnetite nanocrystal for ionic attraction between naturally negative-charged HA and nanocrystal. Magnetic resonant imaging (MRI) study revealed that HA-MNC exhibited en-hanced intra-cellular uptake into HCT-116 (CD44 over-expressed cell line). |
| 저자 |
이유한1, 이해신2, 현택환3, Philip B. Messersmith2, 박태관1
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| 소속 |
1한국과학기술원, 2Northwestern Univ., 3서울대 |
| 키워드 |
hyaluronic acid; iron oxide; MRI; cancer imaging
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| E-Mail |
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