| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Pluronic F127/PVA Mixture with Sol-Gel Transition Behavior as a Tissue Adhesion Barrier Material |
| 초록 |
There are many requirements for anti-adhesion gels to be used as tissue adhesion barriers. They include non-tissue adhesiveness, biodegradability, sterilization stability and non-toxicity in the body. In this study, we prepared LCST-controllable Pluronic F127 and polyvinyl alcohol (PVA) mixtures to be applied as a coatable or injectable tissue adhesion barrier material. The Pluronic F127 gel is expected to have anti-adhesion property. The PVA may act as an absorption retarder of Pluronic F127 gel in the body via hydrogen bonding. The prepared Pluronic F127/PVA mixture gels were stable in gamma irradiation for sterilization and showed stability more than 7 days in PBS solution or body fluid. The gels were also showed effective tissue anti-adhesion as evaluated by the postsurgical peritoneal adhesion behavior through animal study using a rat model. |
| 저자 |
임천수, 오세행, 이진호
|
| 소속 |
한남대 |
| 키워드 |
Sol-gel transition; Tissue adhesion barrier; Pluronic F127; Polyvinyl alcohol(PVA)
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| E-Mail |
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