| 초록 |
To enhance antitumor activity of polymeric drug, we co-grafted D-α-Tocopherol (TOC) and doxorubicin (DOX) with redox-sensitive linker (disulfide bond) to O-carboxymethyl chitosan. Furthermore, PEG-linked target moiety (Herceptin ligand peptide, HER2) was conjugated to specifically target human epidermal growth factor receptor 2(Her2/neu)-overexpressing breast cancer cells. Synthesized TOC and DOX-cografted-carboxymethyl chitosan (OCMTOCDOX) and HER2 ligand peptide-conjugated (HER2-OCMTOCDOX) were confirmed by (1)H NMR and FT-IR analysis. DOX released from HER2-OCMTOCDOX nanoparticles was pH-dependent, which ensures nanoparticles stable in blood circulation and releases DOX within tumor cells. In summary, HER2-OCMTOCDOX nanoparticles was striking functions such as reduce cytotoxicity and anticancer efficacy, and could be a promising nanocarrier in improving the chemotherapy of hydrophobic anticancer drugs. |
