| 초록 |
Minoxidil, one of the most common drugs used in the treatment of alopecia, is usually used as an applied form. Since it is permeated from the skin and delivered into the body, it is easy to be denatured or lost. In this work, we develop the transdermal drug delivery platform through hair follicle using minoxidil encapsulated Hyaluronate – Poly(Lactide-co-Glycolide) nanoparticles (NPs). The NPs are prepared by W/O/W solvent evaporation method and analyzed feasibility as drug delivery carrier. We confirm the NPs show suitable size and excellent loading efficiency. In addition, NPs are uptaken into follicle cells without any significant toxicity. Furthermore, NPs can be permeated through the hair follicle and distributed in surrounding tissue. Taken together, we expect the minoxidil encapsulated HA-PLGA NPs can be exploited for the treatment in alopecia. |
