| 초록 |
In this study, the hyaluronic acid-poly(lactic-co-glycolic acid) nanoparticle (HA-PLGA NP)-incorporated gelatin nanofiber (GE NF/HA-PLGA) complexes are prepared for transdermal drug delivery system (TDDS) that deliver drugs through the skin without damaging skin barriers. Previous studies reported that HA-PLGA NPs can load various drugs and penetrate into the skin. However, it is difficult to fix the solution of NPs on the surface of skin. To resolve these issues, GE NFs are prepared by electrospinning. GE NFs have a three-dimensional structure with high surface area and porosity, so it has the advantage of being able to store relatively more drugs. The results of in vitro release test and histological analysis reveal that the complexes exhibit sustained release behavior. In addition, HA-PLGA NPs can be released from the GE NFs and penetrate into the skin. These results suggest that GE/HA-PLGA complexes can be suitable for novel TDDS. |
