| 초록 |
Among different biocatalysts, ω-transaminases (ω-TAs) have recently received a great deal of attention as promising catalysts due to their ability to produce a wide range of optically pure amines and unnatural amino acids. ω-TA reaction has many desirable features when compared to other enzymes such as hydrolases and dehydrogenases, including broad substrate specificity, high enantioselectivity, high turnover number, and no requirement for regeneration of external cofactors. The use of ω-TAs to produce optically pure chiral amine compounds has been a focus of major research interest, as these compounds are extensively used in pharmaceutical, agricultural, and chemical industries. In this seminar, I will present our recent efforts to produce optically pure unnatural amino acid by using ω-TAs. |
