| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.348 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and characterization of double-layered mesospheres using w/o/w emulsion |
| 초록 | For molecules with narrow therapeutic ranges or high toxicity, several of the drugs could be required controlled release. To eliminate initial burst of drug, mesospheres have been studied. mesospheres made with a two-layered structure may have certain advantages comparing with single layered spheres.1,2 In this study, the dextran(MW=43,000) and poly(D,L-lactide-co-glycolide) 50:50 (PLGA) composite mesospheres were fabricated by a water-in-oil-in-water (w/o/w) double emulsion process.3 Predetermined rates were 1:1, 1:2, 1:3, 2:1 and 3:1 (dextran:PLGA, w/w %). The morphology of mesospheres varied depending on rate of dextran and PLGA. Dextran was dissolved in 0.5㎖of PBS(pH 7.4, containing polyvinylalchol 2 w/v %). After dissolving PLGA in MC, two solutions mixed and sonicated for 5 sec. this solution added in PBS and then freeze dried. As a result, double-layered mesospheres (average size=10㎛) could be fabricated.(그림. 1) The result of HPLC has shown slow release rate. Fig. 1. Particle size of dextran-PLGA mesospheres (average size=10㎛, ×400). Acknowledgment : This work was supported by Nano-Science Core Fundamental Laboratory Program (KMOST) Reference 1. N.A. Rahman, and E. Mathiowitz, J. Con. Rel., 94, 163 (2004). 2. Tai-Shung Chung, and Xin-Lai Bai, Chem. Eng. Sci., 55, 2223 (2000). 3. Yi-Yan Yang, Meng Shi, and Suat-Hong Goh, J. Con. Rel., 88, 201 (2003). |
| 저자 | 안용산1, 문대식1, 홍금덕2, 조선행2, 이종문1, 강길선1 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | dextran; PLGA; double-layed mesospheres |
