| 초록 |
We developed a new type of photocurable and elastomeric hydrogels using biocompatible and biodegradable norbornene-functionalized poly(glycerol sebacate)-co-poly(ethylene glycol) (Nor_PGS-co-PEG) copolymers. Nor_PGS-co-PEG macromers can be crosslinked using 2,2’-(ethylenedioxy)diethanethiol to prepare hydrogels in the presence of light and photoinitiator. The properties (i.e. mechanical property, swelling ratio and degradation rate) of Nor_PGS-co-PEG hydrogels can be modulated using different amount of crosslinkers. In particular, the elongation of Nor_PGS-co-PEG hydrogels can be modulated up to 950%, making it a promising stretchable biomaterials for applications in wound dressing and wearable devices. Nor_PGS-co-PEG hydrogels have been successfully demonstrated in the fabrication of microfibrous scaffolds and 3D printed structures, expanding the utility of PGS-co-PEG materials in biomedical filed using biofabrication techniques. In addition, the cytocompatibility of Nor_PGS-co-PEG was also investigated using in vitro cellular viability studies. Taken together, we have demonstrated that Nor_PGS-co-PEG is an elastomeric biomaterial with highly tailorable properties, making it a versatile hydrogel model for specific applications. |
