| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Multivalent sialyl ligands as inhibitors of influenza viruses |
| 초록 |
The design of multivalent sialyl ligand that conjugate nano-scaffold represents a potential strategy for inhibiting the binding of the influenza virus. In this study, we present a strategy for the synthesis of multivalent sialyl receptor designed to conjugate nano-scaffold with controlled flexibility and valencies. The mono- and multivalent ligand structures were confirmed by 1H-NMR and mass spectroscopy. The antiviral activities of the ligands were investigated by hemagglutination inhibition and fluorescence-based neuraminidase inhibition assays. Synergistic inhibition effect of the multivalent sialyl ligands was observed from the study on influenza virus inhibition of the nano-scaffold (e.g., phage) conjugated with the same ligands. |
| 저자 |
정진효, 정우재, 홍갈렙, 이상현, 정지윤
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| 소속 |
성균관대 |
| 키워드 |
multivalent effect; influenza virus; sialic acid
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| E-Mail |
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