| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Artificial Bone Substitute Composed of MegaGen Synthetic Bone andHA-Cystamine hydrogels for Guided Bone Regeneration |
| 초록 |
A novel artificial bone substitute composed of MegaGen synthetic bone(MGSB) and hyaluronate-cystamine(HA-Cys) hydrogel was successfully developed for guided bone regeneration. Because HA, which is osteo-conductive, plays an important role in bone regeneration, HA-Cys hydrogel was designed to supply HA continuously for efficient bone regeneration by its controlled degradation in vivo. Biphasic MGSB composed of hydroxyapatite and β-tricalcium phosphate(β-TCP) was synthesized by chemical precipitation method and characterized by SEM and X-ray diffraction. In order to assess guided bone regenerability, MGSB and HA-Cys microhydrogels were mixed and implanted to the critical bone defects in vivo. After 4 weeks, MGSB/HA-Cys hydrogels showed excellent performance in osteo-conduction and bone regeneration. The controlled degradation of HA-Cys hydrogels was thought to contribute for guided bone regeneration by continuous provision of osteo-conductive HA. |
| 저자 |
염준석1, 양동준2, 최석규2, 신홍인3, 한세광1
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| 소속 |
1포항공과대, 2(주) 메가젠, 3경북대 |
| 키워드 |
Bone regeneration; Hyaluronic Acid (HA); MegaGen Synthetic Bone (MGSB); Bone substitute; HA hydrogel
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| E-Mail |
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