| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Hyaluronic Acid Hydrogels for Soft and Hard Tissue Engineering Applications |
| 초록 |
A novel protocol to control the molecular degradation of hyaluronic acid (HA) hydrogels was developed using various kinds of crosslinkers for soft and hard tissue engineering applications. The carboxyl group of HA is known to be the recognition site of hyaluronidase and HA receptors. Accordingly, HA hydrogels prepared by the crosslinking of the carboxyl group of HA appeared to be stable longer than 6 months, which were successfully applied for tissue augmentation in wrinkled model mice. In contrast, HA hydrogels with a relatively fast degradation kinetics within 1~2 months were successfully applied for bone tissue engineering. Artificial bone substitute of MegaGen synthetic bone (MGSB) and degradation controlled HA hydrogels implanted to the calvarial critical size bone defects in New Zealand white rabbits resulted in excellent bone regeneration by the continuous provision of osteogenic and angiogenic HA from the HA hydrogels. |
| 저자 |
염준석1, 황의진2, 조일환2, 장소은1, 제정호1, 조동우1, 신홍인3, 한세광1
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| 소속 |
1POSTECH, 2신풍제약, 3경북대 |
| 키워드 |
Hyaluronic Acid (HA); HA hydrogels; Tissue Augmentation; Bone Regeneration; Tissue Engineering
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| E-Mail |
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