| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Differential human mesenchymal stem cell activity in low and high molecular weight hyaluronic acid based hydrogels |
| 초록 |
For optimization of tissue regeneration, hyaluronic acid based hydrogels were prepared with different molecular weight hyaluronic acid (10 KDa, 50 KDa, 130 KDa and 170 KDa). Hydrogel was prepared by Michael type addition reaction with acrylated HA and PEG-SH4. Proliferation and viability of human mesenchymal stem cells cultured in the HA hydrogel showed different depending on the molecular weight of HA. As RGD peptide was introduced by Michael type addition reaction and BMP-2 was incorporated in the hydrogel, cellular viability increased in RGD introduced and RGD+BMP-2 incorporated hydrogel respectively. Gene expressions of hMSCs cultured in various hydrogels were compared. Biological assay of hMSCs in HA based hydrogels shows the basics for effective tissue specific regeneration. |
| 저자 |
김정주1, 박용두2, 이재연3, 박종혁4, 윤소정5, 태기융6, 선경1
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| 소속 |
1Biomedical Engineering, 2Brain Korea 21 Project for Biomedical Science, 3Korea Univ. Medical College / Korea Artificial Organ Center, 4Korea Univ., 5Seoul, 6Korea |
| 키워드 |
human mesenchymal stem cell; hyaluronic acid; hydrogel; gene expression
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| E-Mail |
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