| 초록 |
Recently, the treatment and prophylaxis of H5N1 avian influenza has been of a great social issue. Although many antiviral agents have been developed for inhibiting influenza virus replication, one of the most important drugs currently being used to treat infected patients is oseltamivir (Tamiflu). However, the resistance of H5N1 to oseltamivir has been reported. The main objective of this study is to design a new inhibitor that is more effective against H5N1. For this purpose, we design molecularly a chemical group with the right shape, size and electronic charge to fit snug into the active site of the N1 and as a result we propose a new drug with this group attached to the scaffolding of oseltamivir. This inhibitor shows better binding interaction for N1 neuraminidase than the oseltamivir. To examine the drug efficiency, the binding strengths of the oseltamivir and the new inhibitor for N1 neuraminidase are calculated by using a computer simulation and compared with each other. |
