| 초록 |
This study introduces a new approach to fabricate ceramide particles for enhancing epidermal barrier function using hydrophobically modified bacterial cellulose nanofibrils (BCNFs). The core of ceramide particles shows multi-lamellar structure by the co-assembly of ceramide and fatty alcohol, of which surface is armored by C18 alkyl chain-grafted BCNFs. The stability of ceramide particles is affected by chain lengths of fatty alcohol, indicating longer chain lengths of fatty alcohols further inhibit the formation of isolated crystalline phase. This result attributes to lamellar phase tightly linked by long alkyl chain of fatty alcohol. The content of the grafted C18 alkyl chain on the BCNFs is also critical for the production of stable ceramide particles, which is confirmed by creaming kinetics. Finally, we propose that the ceramide particles play an essential role in improving skin barrier function without damage to the skin through free-surfactant. |
