| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
정밀화학_포스터 |
| 제목 |
Synthesis of 99mTc-based radiotracer for an apoptosis imaging agent and its biological evaluation |
| 초록 |
Synthsis of 99mTc-based radiotracer and its biological evaluation were accomplished for an apoptosis imaging used for the efficacy evaluation of drugs as well as the early detection of cancer. In this study 99mTc-ML-10 derivative was designed and synthesized with high radiochemical yield (84%) and radiochemical purity (＞99%). The radiotracer showed excellent in vitro stability for more than 12 h in mouse serum under ambient conditions. And it was intravenously injected to healthy ICR male mice for the bioditritibtion study and apoptosis was detected in the testes of the mice. The biodistribution study revealed that the radiotracer was accumlated in the testes three times higher than muscle tissue. And it showed fast blood clearance via kidneys. |
| 저자 |
박상현, Sajid Mushtaq, 심하은, 전종호, 최대성
|
| 소속 |
한국원자력(연) |
| 키워드 |
radiotracer; apoptosis imaging
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| E-Mail |
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