| 초록 |
Stem cell therapies hold tremendous promise, but clinical effectiveness has been limited by transplanted cell death, poor engraftment efficiency, and limited control over cell fate in vivo. Biomaterials can bypass the need for ex vivo BMSC manipulation and transplantation by recruiting native BMSCs to aid in regeneration. In this talk, stem cell/growth factor based therapies will be presented to control the fate of BMSC for a disease treatment. Macroporous biomaterials have been used to partially circumvent these problems by improving transplanted stem cell survival and acting as depots that locally deploy cells into damaged tissues. These presentations will also provide recent results indicating that one can control therapeutic behaviors of stem cells in situ using growth factors or mechanochemical cues from engineered materials, and more broadly presents a class of materials that can be used to study the relationship between the molecular cell-matrix interface and cell fate in situ. |
