| 초록 |
Cholesterol is an essential component of cell membranes and performs several roles in body. When cholesterol level in body rises, they form crystals, and these cholesterol crystals (CC) are the cause of atherosclerosis or cholelithiasis. In this research, an arbitrary ratio of lipids were set, and model lipid membrane or oil-water layers were created through various methods to visualize the crystals and then attempt to remove them. When the model lipid membrane was observed with microscope, it was confirmed that MβCD's effect was relatively dominant in removing the crystals already made. Also, cholesterol derivatives did not remove the crystals, but may change the shape of the crystals or delayed crystallization. This result claims that cholesterol derivatives affect the kinetics of cholesterol crystallization, and each component can be classified according to their effect on size, shape, and number of cholesterol crystals if more data are obtained in the future. |
