| 초록 |
Ruthenium(Ⅱ) coordination compounds have rich photophysical properties as Luminescent transition metal complex, which enable newly development of responsive luminescence probes to specifically target and quantify analytes. Here, we developed peptide self-assembled nanostructure(YC7@Au/Ru) using a Tyrosine rich peptide complexed with Ru(Ⅱ) ion and Au(Ⅲ) ion in a shape of sphere type and confirmed by TEM(EDX), UV-vis, PL, UV-vis, XPS and XRD. The resulting YC7@Au/Ru nanostructure was modified with PEG-conjugated folic acid via carboxyl-activation. Confocal microscopy analyses showed that these YC7@Au/Ru nanoparticles could selectively detect cancer cells expressing high-level Folate receptor. The cell viability was confirmed by MTT assay in the presence of YC7@Au/Ru nanostructure. These achievements reveal that YC7@Au/Ru can be applied to cellular uptake, intracellular targeting and cell tracking. Keyword : Ruthenium(II), peptide self-assembly, luminescence probe, cellular imaging |
