| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Preparation of low-molecular-weight chitosan derivative to promote cell adhesion on titanium surface |
| 초록 |
For improving cell adhesion on titanium surface, phosphonated low-molecular-weight chitosan(P-LMC) was prepared by introducing a phosphonate group of 4-phosphonobutyric acid to low-molecular-weight chitosan. The phosphonate group of P-LMC was identified by 31P-NMR. X-ray Photoelectron Spectroscopy (XPS) and water contact angle were carried out for characterization of titanium surface treated with P-LMC. The biocompatibility of P-LMC was demonstrated through a cytotoxicity test using the C2C12 cell line because P-LMC should have no cytotoxicity for applying to dental implant materials. Improvement of cell adhesion on titanium surface treated with P-LMC was observed by microscopy, and the number of attached cells was counted using a hemocytometer. These results demonstrate that P-LMC is biocompatible and titanium surface treated with P-LMC has positive effects on cell adhesion. Therefore, P-LMC is a useful material that can be applied for titanium coating to enhance cell adhesion and osseointegration. |
| 저자 |
손태일, 한가득, 정진홍, 김은혜
|
| 소속 |
중앙대 |
| 키워드 |
Chitosan; Cell adhesion; Titanium surface
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| E-Mail |
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