| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of glycosaminoglycan hydrogels system by radiation technique and their release behaviors and permeation properties |
| 초록 |
Glycosaminoglycans, including hyaluronic acid (HA) and chondroitin sulfate (CS), are aminosugar-containing polysaccharides in the extracellular matrix of all vertebrates. To design the artificial skin model composed of biocompatible natural polymer and synthetic polymer for alternative tests to animal experiments, we synthesized hyaluronic acid and chodroitin sulfate derivatives with polymerizable residues with precise control over the substitution degree. The hyaluronic acid/chodroitin sulfate-based hydrogels were prepared by using a radiation technique. The enzymatic degradation kinetics, the drug release behaviors and drug permeation properties of the hydrogels were investigated to evaluate the feasibility for artificial skin substitutes. |
| 저자 |
신미래1, 자오린린1, 권희정2, 임윤묵2, 노영창2, 김소연1
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| 소속 |
1충남대, 2원자력(연) |
| 키워드 |
hydrogel; tissue engineering; skin substitutes
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| E-Mail |
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