| 초록 |
The biodegradable Poly (D,L-lactic acid–co-glycolic acid) (PLGA) scaffold was prepared by thermally induced phase separation (TIPS) using dioxane as a solvent, water as a nonsolvent. The effect of additives, PEG, PEG-PLGA diblock and NaCl on the fabrication of scaffold was investigated. PLGA with different additive in dioxane/water mixture (87/13, by wt) were tested for the molecular structural effect on cloud-point temperature. Morphology of scaffold was studied by varying processing parameters including quenching temperature, polymer concentration, and molecular structure as a function of aging time. Highly interconnected scaffold were prepared from PLGA-dioxane-water ternary system with additives at lower polymer concentration ( |
