| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
(생물공학) 생리활성 이차대사산물 생산 최신동향 |
| 제목 |
De novo biosynthesis of plants-specific stilbene compounds in E. coli |
| 초록 |
Microbial synthesis of plant secondary metabolites has attracted increasing attention due to their proven beneficial properties and health-promoting effects. However, the difference between the metabolic pathways of microbes and plants is a challenging subject to build a de novo production system of metabolites in microbes. Stilbene, a type of natural phenol, is the precursor to a range of important plant metabolites such as resveratrol. Our strategy demonstrates the microbes for de novo synthesis of resveratrol analogs used a single vector system joined with resveratrol biosynthetic genes and other modified genes. In addition, most artificial de novo biosynthetic pathways are multi-reaction pathways that require a balanced expression of several biosynthetic enzymes. I will introduce our efforts in fine-tuning the expression level of a six-enzyme reaction for the artificial curcumin biosynthesis as a model system. |
| 저자 |
홍영수 |
| 소속 |
한국생명공학(연) |
| 키워드 |
De novo biosynthesis; stilbene; resveratrol; curcumin
|
| E-Mail |
|
