| 초록 |
Biothiols such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) are naturally occurring components of the biological fluid and participate in numerous cellular functions and physiological processes. Their abnormal level can cause a variety of diseases. Therefore, the detection of biothiols consistently attracts researchers to study for various biochemical investigations as well as the diagnosis of related diseases. Polydiacetylene (PDA) is a kind of conjugated polymer formed through the topochemical 1,4-photopolymerization of self-assembled diacetylene monomer. In addition, PDA displays unique optical properties toward external stimuli such as heat, mechanical stress, pH, and various solvents. In this study, we developed a PDA linked with pyridine mercury complex that shows an optical response in the presence of biothiols. Furthermore, by immobilizing the functional PDA to the electrospun nanofiber resulted in the increase of the sensitivity. |
