| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.466 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Release profile of nifedipine(ND) from multi-coated bead by different dissolution media and speed |
| 초록 | Oral delivery is by far the most widely used route for medication. Various methodes have been proposed for the preparation of controlled release dosage forms for oral delivery.1 pellet dosage forms and their formulation design have shown many advantages and flexibility in enhancing therapeutic safety and potency.2 In this study, we observed the release pattern of ND beads fabricated by fluidized-bead spray coating method according to the composition of dissolution media and dissolution speed. In solubility test, ND showed high solubility in dissolution media containing surfactant such as tween80,SLS. Furthermore, release pattern of ND beads was faster SLS solution than tween80 solution. But, there was no effect of dissolution speed in release behavior of ND beads. In conclusion, we could confirm the improved release pattern of ND beads in dissolution media containing surfactant. Table.1 nifedipine(ND) of maximum solubility Fig 1. Dissolution method Fig 2. Paddle speed Acknowledgement : This work was supported by KMOCIE(10011394) Reference 1. Y. M. Sun, Fluidized-bed spray coated porous hydrogel beads for sustained release of diclofenac sodium, J.Control.Release, 47, 247,(1997) 2. H. O. Ho, C. N. Chen, M. T. Sheu, Influence of pluronic F-68 on dissolution and bioavailability characteristics of multiple-layer pellets of nifedipine for controlled release delivery, J.Control.Release, 68, 433, (2000) |
| 저자 | 최경수1, 정성찬2, 조영호1, 이봉2, 김문석3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2부경대, 3한국화학(연) |
| 키워드 | osmotic bead; fluildized bed coating; multiple coating; DDS |
