| 초록 |
The carriers of drug delivery system were designed for release control and site-specific targeting of drug in oral administration Biopolymeric chitosan and alginate were examined as polar carriers, and theophylline and diclofenac sodium as loading drugs. The carriers were prepared in form of w/o/w microsphere for effective drug-delivery. The release behaviors of the carriers were investigated according to combination of mutually different polarties in different pH environment. The surface morphologies of the microspheres were analyzed in comparison with the release-behavior. It was confirmed that the characteristic of components in delivery system, such as biopolymeric carriers, the drugs, and environmenal pH, was affected signficantly in drug-release property. |
