| 초록 |
Functionalized poly(p-xylylenes) constitute an versatile class of reactive polymers that can be prepared in a solventless process via chemical vapor deposition (CVD) polymerization. The resulting ultra-thin coatings are typically pinhole-free and can be conformally deposited onto a wide range of substrates and materials. More importantly, equipped functional groups can serve as anchoring sites for tailoring of biointerface properties via immobilization of biomolecules. These reactive polymers represent a powerful tool of surface engineering for applications in biotechnology. These reactive coatings provide a general route to support commonly used bioorthogonal reactions, such as Huisgen 1,3-dipolar cycloaddition and thio-ene coupling reactions, on a variety of substrate materials. Surface functions can be activated through a simple design of functionally terminated molecules, and the corresponding responses (e.g. anti-protein fouling and controlled cell attachment) are efficiently and accurately manipulated. On the other hand, accessibility of reactive coatings within confined microgeometries was systematically studied, and the preparation of homogeneous polymer thin films within the inner surface of microchannels was demonstrated. Furthermore, surface microstructures and surface patterns using reactive coatings via photopatterning, projection lithography, photoresist technique, vapor-assisted micropatterning in replica structures (VAMPIR), and dip-pen nanolithography (DPN) are introduced. These patterning techniques can be complimentarily used and provide access to precisely confined microenvironments on flat and curved geometries regardless of the underlying material used. Reactive coatings provide a technology platform that creates active, long-term control and may lead to improved mimicry of biological systems for effective bio-functional modifications. |
