| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
Heparinized and multi-crosslinked Tetronic micelle coated stent for treatment of cardiovascular disease |
| 초록 |
The treatment of cardiovascular diseases has been innovated by introduction of drug eluting stent (DES). However DES still face hurdle for occurring restenosis and thrombosis. In this study, the multi-crosslinked micelle and heparin coated the stent was developed for inhibition of that of limitations. To prepare the heparin and multi-micelle coated stent (HPTS), paclitaxel (PTX) loaded Tetronic-tyramine (TA)/dopamine micelle was coated by simple dipping, and then PTX loaded Tetronic-TA micelle and heparin-PEG-TA was coated via enzymatic reaction. PTX loading amount on HPTS was measured to be about 1.2 μg/mm2. In vitro PTX release profile indicated that PTX release amount was controllable from 20 to 100%. Anti-proliferative assay demonstrated that HPTS was inhibited significantly the growth of smooth muscle cells. Obtained results demonstrated that HPTS is great candidate to treat coronary artery diseases. |
| 저자 |
최종훈1, 배인호2, 정명호2, 박기동1
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| 소속 |
1아주대, 2전남대 |
| 키워드 |
drug eluting stent; micelle; heparin; Tetronic; multi-layer
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| E-Mail |
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