| 초록 |
For early diagnosis and consistent follow-ups of chronic diseases, non-invasive sample collection is important in today's aging society. Human saliva may be collected patient-friendly. Allowing simple access, saliva may be easier for patients with diabetes or hemophilia to self-diagnose. Concentrations of many physiological and pathological biomarkers in saliva correlate with them in serum, which makes saliva a promising candidate for biosensing. Salivary biosensors have been widely studied to develop more efficient techniques of both sample loading and sensing. However, current tests have provided low specificity and required prolonged time and professional labor. In this study, a sensor platform is 3D-printed with biocompatible filaments, which design enables simple collection direct delivery of saliva. Nontoxic sponges with high absorbing capacity are used as the collectors. Hydrogel-framed and patterned nanofibers are incorporated for detection. Identification of some biomarkers could be proceeded by enzymatic, and colorimetric methods. Furthermore, Surface-enhanced Raman scattering techniques was appropriate for sensitive measurements of salivary oncology markers. |
