| 초록 |
Stents have been considered as the best method for the treatment of cardiovascular diseases. However, in-stent restenosis, late thrombosis, and delayed re-endothelialization are drawbacks. In this work, we have presented a novel approach of using antioxidant/poly(sulfates) to overcome these limitations such as gallic acid (GA/GAS), quercetin (Qu/QuS) and rutin (Ru/RuS). From the results, it was confirmed that these compounds were successfully grafted on Co-Cr surface. The in vitro proliferation test with endothelial cells was demonstrated to be higher for the poly(sulfates) surface, especially, QuS and RuS, as compared to antioxidants. All antioxidants and poly(sulfates) samples indicated lower SMCs proliferation as compared to Co-Cr sample. In addition, Ru and RuS displayed the lowest tendency toward platelet adhesion. In conclusion, we have opened a window to get rapid re-endothelialization and improve blood compatibility using RuS, for stent application and medical devices. |
