| 학회 |
한국화학공학회 |
| 학술대회 |
2008년 가을 (10/23 ~ 10/24, 부산 BEXCO) |
| 권호 |
14권 2호, p.3336 |
| 발표분야 |
재료 |
| 제목 |
Drug-loading study of gelatin nanoparticles |
| 초록 |
The goal of this study was to investigate the entrapment of three different drugs (Fluconazole, Tizanidine hydrochloride, and Gatifloxacin in gelatin nanoparticles. The particles were prepared by nanoprecipitation method using water or DMSO as solvent and Ethanol as nonsolvent. It led to a homogenous population of nanoparticles except in Tizanidine hydrochloride loaded case, where visible aggregates were found in the system. No loading was achieved in case of Fluconazole, while Tizanidine hydrocholide loaded crosslinked particles showed 16% loading efficiency which was decreased to 1-2% in uncrosslinked case. Contrarily the loading efficiency of Gatifloxacin loaded crosslinked particles was 5-6% and was increased to 15-20% when crosslinking was excluded from the procedure. |
| 저자 |
임광희1, 이은주2, Saeed Ahmad Khan1, Dao Vinh Nam1
|
| 소속 |
1대구대, 2경북대 |
| 키워드 |
Gelatin; Nanoparticle; Drug-loading; Entrapment
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| E-Mail |
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| 원문파일 |
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