| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Controlled Release of Quetiapine Hemifumarate by Wet Granulation with Various Polymers |
| 초록 |
Quetiapine(QT) structured as clozapine or olanzapine dibenzothiazepine derivatives are relevant and effective as anti-psychotic medication. In this study prepared sustained-release tablets of QT by using wet granulation method. Wet granulation tablets were formulated with the various polymers. DSC and XRD were used to analyze both the amorphous and of wet granulation. FT-IR was used to analyze chemical structure of molecule between QT and polymer. The in vitro release behavior of wet granulation presented intestinal juice (pH 6.8). The in vitro test showed sustained-release of QT granule tablet. This study suggests sustained-release of granule QT tablet with polymer, and QT using wet granulation method can be able to improve the bioavailability. This research was supported by NRF-2012M3A9C6050204, Bio-industry Technology Development Program (KMFAFF, 112007-05-2-SB010) and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
박진영, 김혜민, 오승창, 김수민, 국현, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Quetiapine; Polymer; Wet Granulation; Sustained-Release
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| E-Mail |
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