| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dissolution Rate Improvement of Olmesartan Medoxomil Using Water Soluble Polymer and Comparison Dissolution Rate by Excipient |
| 초록 |
Olmesartan medoxomil is a selective angiotensin typeII 1 receptor (AT1R) antagonist. Bioavailability is about 26%. We demonstrated the release behavior of the olmesartan from contents of F-Melt (Type C), calcium phosphate dibasic, potato starch, MCC, n-mannitol and lactose. These mixtures were prepared by granulation method and tablets were prepared using the direct compression method. The characterization of olmesartan and mixtures was analyzed by scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FT-IR). SEM was used to confirm the morphology of drug, carrier, excipient, and mixtures. FT-IR was used to analyze the change in chemical structure of the olmesartan and mixtures. The dissolution study was conducted to find the characterization of dissolution behavior of the olmesartan in the stimulated gastric juice. In this study, the dissolution rate of olmesartan was affected by the excipient. This research was supported by WCU (R31-20029). |
| 저자 |
오승창, 이현구, 김혜윤, 김하늘, 윤현, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
release behavior; excipient; olmesartan medoxomil; dissolution rate
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| E-Mail |
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