| 학회 |
한국재료학회 |
| 학술대회 |
2021년 가을 (11/24 ~ 11/26, 경주 라한호텔) |
| 권호 |
27권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Combined effect of Irisin and Bioglass on MC3T3E1 osteoblasts for bone regeneration |
| 초록 |
Bone injuries results in different movement related complications, which needs high functional grafts with growth factors and delivery systems. To overcome the problems methodologically, regenerative medicine developed and improved certain biomaterial and strategies. This project tries to provides an optimal Irisin and bioglass system for in vivo repair of large bone defects in future studies. The system consists of bioglass, growth factor Irisin and Polyvinyl alcohol. Delivery of bio-glass and irisin seems the best strategy for bone regeneration. The optimized bio glass confirmed as the contents of 45S5 bioglass. More than 80 % (120 to 150 um) porosity generated. Degradation and pH behaviors shows more than 20 % within a week around the pH 7.4. MC3T3E2 osteoblasts showed the significant cells growth and calcium deposition in day 3 by Alizarin staining at 150ng/ml of Irisin loaded on bio-glass. Bone regenerative markers showed the early bone regenerative purposes of Irisin as a growth factor. SEM reports showed the loaded irisin and MC3T3E2 cells elongation and adhesion in pores after loading Irisin. |
| 저자 |
Maqsood Ali1, Lee Byong Taek12
|
| 소속 |
1Institute of Tissue Regeneration, 2College of Medicine |
| 키워드 |
Irisin Bioglass bone regeneration |
| E-Mail |
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